XCapSeq DNA hybridization capture system

Product Introduction     
           The XCapSeq DNA probe capture system consists of probes designed by Xinji's self-developed synthesis platform, low-bias rapid hybridization reagents, groundbreaking affinity magnetic beads, and mass-produced universal blocking reagents.

 

    
Product Advantages     
Excellent long-chain synthesis technology     
Independently developed a unique oligonucleotide synthesis process, greatly improving synthesis stability and solving the problem of instability of purine synthesis in acidic environments in ultra-long chains in traditional chemical synthesis. The coupling efficiency of 120bp DNA chains is greater than 99.5%, and the yield is greater than 50%.

    
 

Unique purification process
Independently developed oligonucleotide synthesis and purification integration technology, not only solves the problem of low purity of ordinary desalting purification process; at the same time, through an integrated synthesis column, the removal of truncated oligonucleotides and the retention of target long-chain oligonucleotides are completed during the synthesis process, and the purity can reach 95%.

 

Comprehensive quality control system
Complies with GMP and ISO13485 quality system requirements. Each probe synthesis undergoes quality control steps such as coupling monitoring, PAGE identification, mass spectrometry detection, and quantitative monitoring.

 


Rapid testing and optimization system

A complete high-standard ICL clinical service platform has been established to provide a full-process verification and optimization platform for the customized development of each Panel, with one round of verification taking only 5 working days.

 

Excellent product performance

Uniformity > 99%, capture efficiency > 75%, suitable for multiplexed systems.

 

 

Superior supporting products to those on the market: Universally designed Blocker with special structure

 

Superior supporting products to those on the market: XCapSeq™ Hyb&Washing Buffer Kit

Note: Using XLIBPrep Fast Library Kit, XCapSeq 120 hotspot Panel, and XCapSeq™ Hyb&Washing Buffer Kit, three replicates were performed for each hybridization time of 1, 2, 4, and 16 hours, a 4-plex hybridization experiment. The results show that under conventional buffer hybridization conditions, regardless of 1, 2, 4, or 16 hours, the capture efficiency, 0.2x average depth, and 0.5x average depth data are similar. XCapSeq™ Hyb&Washing Buffer Kit is suitable for short-time hybridization systems.
 

 

Superior supporting products to those on the market: Mass-produced SA magnetic beads

XCapSeq SA Beads (M270)
 

 

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